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The XCI pattern in these cells can be maintained stability after differentiation .

失活状态在细胞分化后可以稳定的维持。

After long-term culture , epigenetic status of these cells changed , XIST gene expression could be detected accompanied by the occurrence of XCI . 6 .

长期培养后，伴随XCI的发生，XIST基因表达可检出。

Most of the cells have initiated XCI prior to differentiation , and completed XCI after differentiation . 5 .

大部分细胞系在分化前启动了XCI，但在分化过程中逐渐完成XCI。