Conclusions skin changes of arsenism begin from hyperkeratosis , next affected by depigmentation and hyperpigmentation .
结论地方性砷中毒皮肤改变从角化开始，先后出现脱色和色沉。
Arsenic , which is a highly poisonous metalloid , causes acute and chronic adverse health effects , including skin lesions , hyperkeratosis , blackfoot disease and cancer .
砷是一种剧毒的类金属，能引起机体急性和慢性损伤包括皮肤损害、角化过度、黑脚病、癌症。
Resent research found that the inherited or acquired pathophysiologic factors can damage the skin barrier function , which could lead to hyperkeratosis , epidermal hyperplasia and inflammatory reaction .
Histopathology of lesions in patient 2 revealed hyperkeratosis , hypergranulosis , acanthosis , elongation of trochanterellus , and small inflammatory infiltrates around blood vessels in upper dermis .
例2皮损组织病理检查：角化过度，棘层及颗粒层增厚，表皮突延长，真皮浅层血管周围少量炎性细胞浸润。
The nail bed thickens and hardens ( nail bed hyperkeratosis ) , and inflammation of the nail fold is observed in chronic mucocutaneous disease ( disease of mucous membrane and regular skin ) .
