This work provides the structural basis for the recognition and combination of APC to Asef and DLG , as well as the potential targets for pharmaceutical development .
In human hereditary and sporadic colorectal cancers , human tumor suppressor APC is always observed as a mutant or truncated form and thus continuously activates Asef and promotes cell migration and angiogenesis .
This paper show a method : first through the average of synthetic exact filter ( ASEF ) to obtain the location of the human eye then change the face rotation by affine transformation , and finally to the frontal face of the approximate standard .
