Newton st loe 's oldest buildings date from the 15th century , and it has changed little in recent years .
牛顿圣洛最古老的建筑始建于公元15世纪，近年来几乎没有变化。
Barbara loe fisher , co-founder and president of the national vaccine information center , which supports more research into the safety of vaccinations , said autism is just one concern linked to vaccines .
According to iain loe of camra , a group dedicated to promoting good beer , 99 commercial breweries opened in britainin the yearto june 2010 , boosting the total to 840 .
