1823 In italy the active ingredient is extracted from willow and named salicin .
1823年，在意大利，从柳树中提取出有用的成分，命名为水杨苷。
By 1897 a synthetic derivative ( acetyl salicylic acid ) of the plant 's active ingredient ( salicin ) was created .
1897年前后，一种从植物活性原料（水杨苷）中萃取出来的一种合成衍生物（乙酰基水杨酸）被研制出来。
The " spir " came from the spirea plant , which also produces salicin .
在“符号或者交互”来自斯皮雷亚工厂，也能制造酸。
However , when the active ingredient salicin was converted to the medicine salicylic acid it was hard to swallow , causing irritation to the lining of the mouth and stomach .
