The first is extremely resistant to nucleophilic reagents .
前者极端地阻抗亲核试剂。
The carbon should be susceptible to attack by a nucleophilic species .
碳容易被亲核试剂进攻。
Directing effects in electophilic aromatic substitution . Nucleophilic aromatic substitution . Strategies in the synthesis of multisubstituted benzene derivatives .
In this paper , the recent progress of organic reactions in aqueous media , such as condensation reaction , nucleophilic substitution reaction , cycloaddition reactions , barbier-type and multi-component reaction , and their applications are reviewed .
