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An overdose killed his eldest daughter ; an adopted son was estranged .

服药过量夺走了他大女儿的生命，他与养子关系疏远。

Then came the iraq war , which estranged london 's continental partners .

随后而至的伊拉克战争，更是疏远了英国和欧洲大陆伙伴的关系。

And this is no dysfunctional family , with family members estranged from one another .

而这个家庭并不是什么支离破碎的地方，家庭成员之间也不会彼此疏远。

People questioned later in life often say their biggest regret is being estranged from a sister or brother .

在晚年时接受调查的人很多都会说，他们最大的遗憾是被某一位姐妹或者兄弟疏远。

Both grew up estranged from their white heritage , in part , because of a sense of shame .

这两位都是从小就与他们的白人亲属非常疏远，部分原因是出于羞耻。