When pidd levels are artificially increased in human lung cancer cells , they become more resistant to cisplatin .
当pidd水平在肺癌细胞人为增加时，它们对顺铂耐药性增强。
After four doses of cisplatin , mice with normal p53 developed resistance to the drug , and tumors started growing faster .
在四个顺铂剂量之后，有正常p53的小鼠获得了药物的耐药性，肿瘤开始加速生长。
Now , mit cancer biologists have shown how that resistance arises , a finding that could help researchers design new drugs that overcome cisplatin resistance .
The researchers found that cisplatin was effective against lung tumors in both sets of mice , though it was more potent in mice that still had functional p53 .
